Pax6: more than meets the eye.

Trends in genetics : TIG ·Vol. 11 ·No. 7 ·1995-07-00 ·Pages 268-72

Hanson I, Van Heyningen V

Abstract

The paired-box motif, originally defined in Drosophila segmentation genes is conserved in the Pax family of vertebrate developmental genes. Mutations that reduce Pax6 dosage cause dominantly inherited eye malformations in man and mouse. Remarkably, it has now been found that Drosophila has a homologue of Pax6, which also plays a key role in eye development.

Related Genes

Pax6

MeSH Terms

Animals Aniridia/genetics Biological Evolution DNA-Binding Proteins/genetics,physiology Drosophila/genetics Eye Abnormalities/genetics Eye Proteins Gene Dosage Homeodomain Proteins Humans Mice PAX6 Transcription Factor Paired Box Transcription Factors Repressor Proteins

Chemicals

DNA-Binding Proteins Eye Proteins Homeodomain Proteins PAX6 Transcription Factor PAX6 protein, human Paired Box Transcription Factors Pax6 protein, mouse Repressor Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hanson I

MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.

Van Heyningen V

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

DOI

10.1016/s0168-9525(00)89073-3

Published

1995-07-00

Pages

268-72

Language

English

Region

England

NLM ID

8507085

Subset

Grants

Medical Research Council · MC_U127527199 · United Kingdom

External Links

PubMed source DOI: 10.1016/s0168-9525(00)89073-3 View journal details

Analysis Services

Pax6: more than meets the eye.

Contact

WeChat Official Account