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PMID: 7498786 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

Genes & development ·Vol. 9 ·No. 23 ·1995-12-01 ·Pages 2888-902

Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L, Boeke JD

Abstract

Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals. At least three HST genes can function in silencing; HST1 overexpression restores transcriptional silencing to a sir2 mutant and hst3 hst4 double mutants are defective in telomeric silencing. In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes.

MeSH Terms

Amino Acid Sequence Animals Cell Cycle/genetics Chromosomes, Fungal Conserved Sequence DNA-Binding Proteins/chemistry,genetics Fibroblast Growth Factor 4 Fibroblast Growth Factors/chemistry,genetics Gene Dosage Gene Expression Regulation Genes, Fungal/radiation effects Histone Deacetylases Humans Molecular Sequence Data Mutation Proto-Oncogene Proteins/chemistry,genetics Saccharomyces cerevisiae/genetics,radiation effects Saccharomyces cerevisiae Proteins Sequence Alignment Sequence Homology, Amino Acid Silent Information Regulator Proteins, Saccharomyces cerevisiae Sirtuin 1 Sirtuin 2 Sirtuins Telomere Temperature Trans-Activators/chemistry,genetics Transcription, Genetic Ultraviolet Rays

Chemicals

DNA-Binding Proteins FGF4 protein, human Fibroblast Growth Factor 4 Proto-Oncogene Proteins Saccharomyces cerevisiae Proteins Silent Information Regulator Proteins, Saccharomyces cerevisiae Trans-Activators Fibroblast Growth Factors Hst3 protein, S cerevisiae Hst4 protein, S cerevisiae SIR2 protein, S cerevisiae SIRT1 protein, human Sirtuin 1 Sirtuin 2 Sirtuins Histone Deacetylases

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Brachmann C B

Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA.

Sherman J M

Devine S E

Cameron E E

Pillus L

Boeke J D

Article Info

Journal

Genes & development

Abbr.

Genes Dev

ISSN

0890-9369

DOI

10.1101/gad.9.23.2888

Published

1995-12-01

Pages

2888-902

Language

English

Region

United States

NLM ID

8711660

Subset

Databases

GENBANK

F00550, F11858, H06548, H06578, H11816, H14246, R07921, R13142, R15236, R16487, R24561, R25838, R56596, T66100, T81280, T83544, Z42780, Z50177

External Links

PubMed source DOI: 10.1101/gad.9.23.2888 View journal details

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The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

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