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PMID: 750113 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Metabolism of factor B of serum complement in rheumatoid arthritis.

Clinical and experimental immunology ·Vol. 34 ·No. 1 ·1978-10-00 ·Pages 1-9

Krick EH, De Heer DH, Kaplan RA, Arroyave CM, Vaughan JH

Abstract

An increased rate of catabolism of radio-iodinated Factor B has been shown in five out of ten patients with rheumatoid arthritis. Serum levels of Factor B were normal, the increased catabolism being matched by increased synthesis. The patients showing high catabolic rates had more manifestations of extra articular disease than did those with normal catabolic rates and they had higher rheumatoid factor titres. In seven patients, the catabolic rate for Factor B correlated significantly with the rate of IgG catabolism. In this series, the Raji-cell assay for immune complex-like material was in the normal or near normal range in all but one patient.

MeSH Terms
Adult Aged Antigen-Antibody Complex Arthritis, Rheumatoid/immunology Complement Factor B/metabolism Enzyme Precursors/metabolism Humans Immunoglobulin G/metabolism Middle Aged Rheumatoid Factor/analysis
Chemicals
Antigen-Antibody Complex Enzyme Precursors Immunoglobulin G Rheumatoid Factor Complement Factor B
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Krick E H
De Heer D H
Kaplan R A
Arroyave C M
Vaughan J H
References (43)
43 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1978-10-00
Pages
1-9
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1537473
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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