The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin.

Nucleic acids research ·Vol. 23 ·No. 21 ·1995-11-11 ·Pages 4229-33

Koonin EV, Zhou S, Lucchesi JC

Abstract

Using computer methods for detecting conserved amino acid sequence motifs, we show that the chromatin organization modifier (chromo) domain that has been previously identified in several proteins involved in transcription down-regulation is present in a much larger group of (putative) chromatin-binding proteins, some of which are positive rather than negative regulators of transcription. The most interesting new members of the chromo superfamily are Drosophila male-specific lethal (MSL-3) protein involved in the X chromosome gene dosage compensation in the males and human retinoblastoma-binding protein RBP-1. We show that the chromo domain is duplicated in several chromatin-binding proteins and use this observation to interpret recent results on chromatin binding obtained with chimeric chromo domain-containing proteins. We hypothesize that the chromo domain may be a vehicle that delivers both positive and negative transcription regulators to the sites of their action on chromatin.

MeSH Terms

Amino Acid Sequence Carrier Proteins/chemistry,genetics,metabolism Chromatin/metabolism Chromobox Protein Homolog 5 Chromosomal Proteins, Non-Histone Conserved Sequence Drosophila Proteins Models, Molecular Molecular Sequence Data Multigene Family Nuclear Proteins/chemistry,genetics,metabolism Polycomb Repressive Complex 1 Protein Structure, Tertiary Proteins Repetitive Sequences, Nucleic Acid Sequence Analysis Sequence Homology, Amino Acid Transcription Factors/chemistry,genetics,metabolism

Chemicals

Carrier Proteins Chromatin Chromosomal Proteins, Non-Histone Drosophila Proteins Nuclear Proteins Pc protein, Drosophila Proteins Transcription Factors Chromobox Protein Homolog 5 msl-3 protein, Drosophila Polycomb Repressive Complex 1

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Koonin E V

National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894, USA.

Zhou S

Lucchesi J C

References (36)

36 references, click to expand

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/23.21.4229

Published

1995-11-11

Pages

4229-33

Language

English

Region

England

NLM ID

0411011

PMCID

PMC307373

Subset

Databases

GENBANK

D14812, D15421, D24751, L07515, L19339, L34658, M57574, T02521, T36139, U19103, Z20674, Z36753

PIR

A43906, S23571, S46942, S48828, S66427

SWISSPROT

P23197, P23198, P26017, P29227, P30658, P32657, P34618, P40201, P40381, Q02084

External Links

PubMed source DOI: 10.1093/nar/23.21.4229 PMC Full Text View journal details

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The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin.

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