Nitric oxide and biopterin: a study in Chiaroscuro.

The Journal of clinical investigation ·Vol. 93 ·No. 5 ·1994-05-00 ·Pages 1875-6

Nathan C

Abstract

暂无摘要

MeSH Terms

Amino Acid Oxidoreductases/metabolism Animals Biopterin/metabolism Endothelium, Vascular/metabolism Humans Macrophages/metabolism Muscle, Smooth/metabolism Nitric Oxide/metabolism Nitric Oxide Synthase

Chemicals

Biopterin Nitric Oxide Nitric Oxide Synthase Amino Acid Oxidoreductases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Nathan C

References (12)

12 references, click to expand

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.
J Biol Chem. 1992 Dec 25;267(36):25722-9 PMID: 1281471
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor.
J Biol Chem. 1989 Nov 25;264(33):19654-8 PMID: 2584186
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.
J Biol Chem. 1989 Dec 5;264(34):20496-501 PMID: 2584226
Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts.
J Exp Med. 1990 Dec 1;172(6):1599-607 PMID: 2124251
Calmodulin is a subunit of nitric oxide synthase from macrophages.
J Exp Med. 1992 Aug 1;176(2):599-604 PMID: 1380065
Nitric oxide as a secretory product of mammalian cells.
FASEB J. 1992 Sep;6(12):3051-64 PMID: 1381691
Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.
J Clin Invest. 1994 May;93(5):2236-43 PMID: 7514193
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.
J Biol Chem. 1993 Jan 25;268(3):1842-6 PMID: 7678411
Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.
Circ Res. 1993 Jul;73(1):205-9 PMID: 7685252
Nitric oxide synthase structure and mechanism.
J Biol Chem. 1993 Jun 15;268(17):12231-4 PMID: 7685338
Induction of a macrophage-like nitric oxide synthase in cultured rat aortic endothelial cells. IL-1 beta-mediated induction regulated by tumor necrosis factor-alpha and IFN-gamma.
J Immunol. 1993 Sep 15;151(6):3283-91 PMID: 7690801
The L-arginine-nitric oxide pathway.
N Engl J Med. 1993 Dec 30;329(27):2002-12 PMID: 7504210

Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI117176

Published

1994-05-00

Pages

1875-6

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC294292

Subset

Corrections

CommentOn

PMID: 7514193

External Links

PubMed source DOI: 10.1172/JCI117176 PMC Full Text View journal details

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Nitric oxide and biopterin: a study in Chiaroscuro.

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