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PMID: 7515527 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Spontaneous Ca2+ spikes and waves in embryonic neurons: signaling systems for differentiation.

Trends in neurosciences ·Vol. 17 ·No. 3 ·1994-03-00 ·Pages 115-8

Spitzer NC

Abstract

Many excitable cells are specialized to promote Ca2+ influx at early stages of development. This article focuses on spontaneous fluctuations of intracellular Ca2+ that are observed during this period. Removal of Ca2+ or suppression of influx alters subsequent differentiation. Thus these signals appear to regulate aspects of early maturation.

MeSH Terms
Animals Calcium/metabolism,physiology Cell Differentiation/physiology Humans Nervous System/cytology,embryology Nervous System Physiological Phenomena Neurons/metabolism,physiology Signal Transduction/physiology
Chemicals
Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Spitzer N C
Dept of Biology, University of California, San Diego, La Jolla 92093.
Article Info
Journal
Trends in neurosciences
Abbr.
Trends Neurosci
ISSN
0166-2236
DOI
10.1016/0166-2236(94)90120-1
Published
1994-03-00
Pages
115-8
Language
English
Region
England
NLM ID
7808616
Subset
IM
Grants
NINDS NIH HHS · NS 15918 · United States
NINDS NIH HHS · NS 25916 · United States
External Links
PubMed source DOI: 10.1016/0166-2236(94)90120-1 View journal details
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