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PMID: 7516400 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Hailey-Hailey disease is not allelic to Darier's disease.

The Journal of investigative dermatology ·Vol. 102 ·No. 6 ·1994-06-00 ·Pages 992-3

Welsh EA, Ikeda S, Peluso AM, Bonifas JM, Bare JW, Woodley DT, Epstein EH

Abstract

Hailey-Hailey (Familial Benign Chronic Pemphigus) Disease is a rare autosomal dominant disorder characterized by blisters caused by suprabasal epidermal acantholysis. Another autosomal dominant skin disease, Darier's disease, has clinical and histologic features which overlap those of Hailey-Hailey disease and recently has been mapped to chromosome 12q23-q24.1. We have used linkage analysis to test whether or not a mutation in this region might also underlie Hailey-Hailey disease. This analysis, using polymorphic loci tightly linked to Darier's disease, excluded this region as the site for the disease-causing mutation in two kindreds affected with Hailey-Hailey disease.

MeSH Terms

Adolescent Adult Alleles Carrier Proteins/genetics Chromosome Mapping Chromosomes, Human, Pair 12 Cytoskeletal Proteins/genetics Darier Disease/genetics Desmoplakins Family Health Female Genetic Linkage Genotype Humans Hyaluronan Receptors Keratins/genetics Male Membrane Proteins/genetics Middle Aged Mutation Pedigree Pemphigus, Benign Familial/genetics Receptors, Cell Surface/genetics Receptors, Lymphocyte Homing/genetics

Chemicals

Carrier Proteins Cytoskeletal Proteins Desmoplakins Hyaluronan Receptors Membrane Proteins Receptors, Cell Surface Receptors, Lymphocyte Homing loricrin Keratins

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Welsh E A

Department of Dermatology, Stanford University School of Medicine, California.

Ikeda S

Peluso A M

Bonifas J M

Bare J W

Woodley D T

Epstein E H

Article Info

Journal

The Journal of investigative dermatology

Abbr.

J Invest Dermatol

ISSN

0022-202X

DOI

10.1111/1523-1747.ep12384283

Published

1994-06-00

Pages

992-3

Language

English

Region

United States

NLM ID

0426720

Subset

Grants

NIAMS NIH HHS · AR41120 · United States

NIAMS NIH HHS · AR41700 · United States

NIAMS NIH HHS · P01 AR4015 · United States

Corrections

CommentIn

PMID: 8006442

External Links

PubMed source DOI: 10.1111/1523-1747.ep12384283 View journal details

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Hailey-Hailey disease is not allelic to Darier's disease.

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