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PMID: 7525887 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The role of tissue inhibitor of metalloproteinase-1 in specific aspects of cancer progression and reproduction.

Journal of neuro-oncology ·Vol. 18 ·No. 2 ·1994-00-00 ·Pages 123-7

Khokha R, Waterhouse P

Abstract

Tissue inhibitors of metalloproteinases (TIMPs) are specific inhibitors of the multi member family of matrix metalloproteinases (MMPs). Since MMP function is fundamental to events that require tissue remodelling, TIMPs regulate normal biological processes by inhibiting MMPs, and are of importance in pathological conditions. In this chapter we review evidence for the suppressive role of TIMP-1 in the malignant progression of cancer and of its regulatory function in controlling invasion during blastocyst implantation and development.

MeSH Terms
Cell Division/physiology Glycoproteins/physiology Metalloendopeptidases/antagonists & inhibitors Neoplasm Invasiveness Neoplasm Metastasis Neoplasms/blood supply,pathology,physiopathology Neovascularization, Pathologic/physiopathology Reproduction/physiology Tissue Inhibitor of Metalloproteinases
Chemicals
Glycoproteins Tissue Inhibitor of Metalloproteinases Metalloendopeptidases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Khokha R
Department of Oncology, London Regional Cancer Centre, University of Western Ontario.
Waterhouse P
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Article Info
Journal
Journal of neuro-oncology
Abbr.
J Neurooncol
ISSN
0167-594X
DOI
10.1007/BF01050418
Published
1994-00-00
Pages
123-7
Language
English
Region
United States
NLM ID
8309335
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01050418 View journal details
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