Role of TCR zeta chain in T cell development and selection.

Science (New York, N.Y.) ·Vol. 266 ·No. 5187 ·1994-11-11 ·Pages 1047-50

Shores EW, Huang K, Tran T, Lee E, Grinberg A, Love PE

Abstract

Signals mediated by the T cell receptor (TCR) are required for thymocyte maturation and selection. To examine the role of TCR zeta chain signals in development, TCR expression was restored in zeta-deficient mice with transgenic zeta chains that partially or completely lacked sequences required for signal transduction. The zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection.

MeSH Terms

Amino Acid Sequence Animals Antigens, CD/analysis,genetics Antigens, Differentiation, T-Lymphocyte/analysis CD4 Antigens/analysis CD5 Antigens CD8 Antigens/analysis DNA-Binding Proteins Down-Regulation Gene Expression Homeodomain Proteins Lectins, C-Type Lymph Nodes/immunology Membrane Proteins/genetics,physiology Mice Mice, Transgenic Molecular Sequence Data Proteins/genetics RNA, Messenger/genetics,metabolism Receptors, Antigen, T-Cell/genetics,physiology Signal Transduction T-Lymphocytes/cytology,immunology Thymus Gland/immunology

Chemicals

Antigens, CD Antigens, Differentiation, T-Lymphocyte CD4 Antigens CD5 Antigens CD69 antigen CD8 Antigens DNA-Binding Proteins Homeodomain Proteins Lectins, C-Type Membrane Proteins Proteins RNA, Messenger Rag2 protein, mouse Receptors, Antigen, T-Cell V(D)J recombination activating protein 2 antigen T cell receptor, zeta chain RAG-1 protein

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Shores E W

Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892.

Huang K

Tran T

Lee E

Grinberg A

Love P E

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.7526464

Published

1994-11-11

Pages

1047-50

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.7526464 View journal details

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