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PMID: 7536012 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model.

Current opinion in immunology ·Vol. 6 ·No. 6 ·1994-12-00 ·Pages 913-20

Singer GG, Carrera AC, Marshak-Rothstein A, Martínez C, Abbas AK

Abstract

Proteins encoded by the fas and fas ligand (fasL) genes are involved in apoptotic cell death in lymphocytes. In this article we review the recent elucidation of the role of the Fas-FasL interactions in the maintenance of tolerance to self antigens and in the homeostatic regulation of lymphocyte clonal expansion, and discuss the mechanisms of autoimmunity in Fas- and FasL-deficient mutant mouse strains.

MeSH Terms

Animals Antigens, Surface/immunology Apoptosis Autoantigens/immunology Autoimmunity Disease Models, Animal Fas Ligand Protein Humans Immune Tolerance Lymphoproliferative Disorders/genetics,immunology Membrane Glycoproteins/immunology Mice Mice, Mutant Strains fas Receptor

Chemicals

Antigens, Surface Autoantigens FASLG protein, human Fas Ligand Protein Fasl protein, mouse Membrane Glycoproteins fas Receptor

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Singer G G

Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.

Carrera A C

Marshak-Rothstein A

Martínez C

Abbas A K

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/0952-7915(94)90013-2

Published

1994-12-00

Pages

913-20

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/0952-7915(94)90013-2 View journal details

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Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model.

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