Chemotaxis and movement of Physarum polycephalum and its responses to some neurotransmitters and psychomimetic compounds.

A method was developed for studying the effect of some neurotransmitters and drugs on the rate of movement and the chemotactic value of the plasmodium of Physarum polycephalum. Epinephrine (adrenaline) at a concentration of 1 mg/ml, reduced the rate of movement and shortened the length of the cycles of shuttle streaming, but did not affect the chemotactic response. The drugs DL-amphetamine, cannabinol and heroin diminished the rate of movement, whereas Na-barbitol misled the chemotactic response.