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PMID: 7543878 Published · ppublish English Journal Article Review

Cytokines as adjuvants for vaccines: antigen-specific responses differ from polyclonal responses.

Infection and immunity ·Vol. 63 ·No. 9 ·1995-09-00 ·Pages 3241-4

Taylor CE

Abstract

The use of cytokines in the administration of vaccines has a unique value in obtaining the appropriate immune response and in ensuring a protective outcome. Earlier studies indicating that cytokines can influence the generation of a particular antibody isotype may represent an oversimplification of a more complex problem. Several studies discussed in this review show that the effect of a given cytokine on the immune response depends on whether one examines the antigen-specific response or the polyclonal response (i.e., total serum immunoglobulins). Further, a balanced regulation of immune responsiveness is important in maintaining homeostasis of the immune system. Consequently, for any vaccine that uses cytokines to boost the response, due consideration must be given to these important variables.

MeSH Terms
Adjuvants, Immunologic/pharmacology Animals Antibody Formation/drug effects B-Lymphocytes/immunology Cytokines/pharmacology Epitopes Humans Vaccines/immunology
Chemicals
Adjuvants, Immunologic Cytokines Epitopes Vaccines
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Taylor C E
Division of Microbiology & Infectious Diseases, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20892-7630, USA.
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.63.9.3241-3244.1995
Published
1995-09-00
Pages
3241-4
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC173446
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.63.9.3241-3244.1995 PMC Full Text View journal details
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