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PMID: 7545872 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma.

The American journal of pathology ·Vol. 147 ·No. 3 ·1995-09-00 ·Pages 564-73

Qu Z, Liebler JM, Powers MR, Galey T, Ahmadi P, Huang XN, Ansel JC, Butterfield JH, Planck SR, Rosenbaum JT

Abstract

Mast cells play an essential role during development of inflammation after chemical and immunological insults and have been implicated in tissue fibrosis and angiogenesis. The exact contribution of mast cells to these conditions is largely unknown. In this study, we found that a potent angiogenic and mitogenic polypeptide, basic fibroblast growth factor (bFGF), is localized to the majority of mast cells from normal skin and lung and in tissue samples characterized by fibrosis, hyperplasia, and neovascularization. Using specific antibodies to mast cell tryptase, tissue macrophage, and bFGF, we demonstrate that cytoplasmic bFGF immunoreactivity is localized to 96.8 +/- 9.6% of tryptase-positive cells in human fibrotic lung tissue (n = 10), 82.3 +/- 6.9% of tryptase-positive cells in rheumatoid synovia (n = 6), and 93.1 +/- 4.8% of tryptase-positive cells in skin hemangioma (n = 5). Moreover, these tryptase-positive cells comprise a major portion (86 to 97%) of nonvascular cells exhibiting cytoplasmic bFGF staining in these tissues. In contrast, macrophage-like cells contribute less than 10% of the bFGF-positive cells in the same samples. The specificity of the immunostaining results was supported by the finding that cultured human mast cells (HMC-1) express both bFGF mRNA and protein. Our data indicate that mast cells, a primary source of heparin, also serve as a significant source of a heparin-binding growth factor, bFGF, in these disease processes. These observations suggest that mast cells may contribute to these pathological conditions by releasing this polypeptide.

MeSH Terms
Arthritis, Rheumatoid/metabolism,pathology Base Sequence Cell Line Fibroblast Growth Factor 2/metabolism Hemangioma/metabolism,pathology Humans Immunohistochemistry/methods Mast Cells/metabolism Molecular Probes/genetics Molecular Sequence Data Pulmonary Fibrosis/metabolism,pathology RNA, Messenger/metabolism Skin Neoplasms/metabolism,pathology Staining and Labeling
Chemicals
Molecular Probes RNA, Messenger Fibroblast Growth Factor 2
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Qu Z
Department of Cell Biology and Anatomy, Oregon Health Sciences University, Casey Eye Institute, Portland 97201, USA.
Liebler J M
Powers M R
Galey T
Ahmadi P
Huang X N
Ansel J C
Butterfield J H
Planck S R
Rosenbaum J T
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1995-09-00
Pages
564-73
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1870968
Subset
IM
Grants
NEI NIH HHS · EY 00318 · United States
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