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PMID: 7546210 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

High endothelial venules (HEVs): specialized endothelium for lymphocyte migration.

Immunology today ·Vol. 16 ·No. 9 ·1995-09-00 ·Pages 449-57

Girard JP, Springer TA

Abstract

High endothelial venules (HEVs) are specialized postcapillary venules found in lymphoid tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean-Philippe Girard and Timothy Springer highlight the unique properties of HEV endothelium, discuss the molecular mechanisms controlling HEV specialization and review evidence suggesting that HEVs could play an important role in the pathogenesis of chronic inflammatory diseases.

MeSH Terms

Animals Antigens, Surface/metabolism Biomarkers Blood-Brain Barrier/immunology Cell Movement Endothelium, Lymphatic/cytology,immunology Glycosylation Humans Inflammation/etiology L-Selectin/metabolism Lymphocytes/cytology,immunology Membrane Proteins

Chemicals

Antigens, Surface Biomarkers L-selectin counter-receptors Membrane Proteins L-Selectin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Girard J P

Laboratoire de Biologie Moléculaire Eucaryote (LBME) du CNRS, Toulouse, France.

Springer T A

Article Info

Journal

Immunology today

Abbr.

Immunol Today

ISSN

0167-5699

DOI

10.1016/0167-5699(95)80023-9

Published

1995-09-00

Pages

449-57

Language

English

Region

England

NLM ID

8008346

Subset

Grants

NCI NIH HHS · CA 31798 · United States

External Links

PubMed source DOI: 10.1016/0167-5699(95)80023-9

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