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PMID: 7546379 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Intrathymic and extrathymic clonal deletion of T cells.

Current opinion in immunology ·Vol. 7 ·No. 2 ·1995-04-00 ·Pages 196-205

Sprent J, Webb SR

Abstract

Clonal elimination accounts for self-tolerance induction in the thymus and also affects mature T cells responding to exogenous antigens in the periphery. Recent evidence on the microenvironments, cell-cell interactions and signalling requirements for clonal deletion of immature and mature T cells is discussed.

MeSH Terms
Animals Clonal Deletion/immunology T-Lymphocytes/immunology Thymus Gland/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sprent J
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
Webb S R
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/0952-7915(95)80004-2
Published
1995-04-00
Pages
196-205
Language
English
Region
England
NLM ID
8900118
Subset
IM
Grants
NCI NIH HHS · CA25803 · United States
NCI NIH HHS · CA38355 · United States
NCI NIH HHS · CA41993 · United States
External Links
PubMed source DOI: 10.1016/0952-7915(95)80004-2 View journal details
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