Mouse NK1+ T cells.

Current opinion in immunology ·Vol. 7 ·No. 3 ·1995-06-00 ·Pages 367-74

Bendelac A

Abstract

Mouse NK1+ T cells constitute a special subset of alpha beta TCR+ T cells that express natural killer surface receptors and are thought to play an immunoregulatory role because of their unique ability to secrete IL-4 within minutes of primary activation. The recent discovery that they recognize non-polymorphic MHC class I like ligands encoded by CD1 family genes sheds a new light on unusual aspects of their development as well as on some of the possible ways in which they might influence the regulation of the T-helper cell (types 1 and 2) classes of immune responses.

MeSH Terms

Amino Acid Sequence Animals Antigens, CD1/immunology Base Sequence CD4-Positive T-Lymphocytes/immunology Epitopes Histocompatibility Antigens Class I/immunology Killer Cells, Natural/immunology,physiology Lymphocyte Activation Mice/immunology Mice, Inbred Strains Mice, Knockout Mice, Nude Mice, Transgenic Models, Immunological Molecular Sequence Data Phenotype Receptors, Antigen, T-Cell, alpha-beta/genetics,immunology Spleen/immunology T-Lymphocyte Subsets/immunology,physiology Thymus Gland/immunology

Chemicals

Antigens, CD1 Epitopes Histocompatibility Antigens Class I Receptors, Antigen, T-Cell, alpha-beta

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Bendelac A

Department of Molecular Biology, Princeton University, New Jersey 08544, USA.

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/0952-7915(95)80112-x

Published

1995-06-00

Pages

367-74

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/0952-7915(95)80112-x View journal details

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