Molecular mechanisms underlying functional T-cell unresponsiveness.

Current opinion in immunology ·Vol. 7 ·No. 3 ·1995-06-00 ·Pages 375-81

Mueller DL, Jenkins MK

Abstract

Evidence from tissue culture experiments and in vivo studies indicates that certain forms of antigen presentation render T cells unresponsive to subsequent antigenic stimulation. Great progress has been made recently in understanding the induction, maintenance, and in vivo relevance of this unresponsive state, called clonal anergy.

MeSH Terms

Animals Cells, Cultured Humans Immune Tolerance Immunocompetence Interleukin-2/biosynthesis,immunology Mice Mice, Transgenic Models, Immunological Signal Transduction/immunology T-Lymphocytes/immunology

Chemicals

Interleukin-2

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mueller D L

University of Minnesota Medical School, Department of Medicine, Minneapolis 55455, USA.

Jenkins M K

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/0952-7915(95)80113-8

Published

1995-06-00

Pages

375-81

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/0952-7915(95)80113-8 View journal details

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