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PMID: 7558313 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Association of lysogenic bacteriophage MAV1 with virulence of Mycoplasma arthritidis.

Infection and immunity ·Vol. 63 ·No. 10 ·1995-10-00 ·Pages 4016-23

Voelker LL, Weaver KE, Ehle LJ, Washburn LR

Abstract

Mycoplasma arthritidis causes a severe polyarthritis under natural conditions in rats and under experimental conditions in both rats and mice. Although the disease itself has been extensively studied, M. arthritidis virulence factors remain uncharacterized. Comparison of relative arthritogenicity of 20 strains of M. arthritidis revealed that the strains tended to fall into two groups, a highly arthritogenic group, inducing maximum arthritis scores of > or = 11 in rats, and a low-virulence group, inducing maximum scores of < 6. Chromosomal DNA from the more highly arthritogenic strains possessed sequences that hybridized by Southern analysis with a probe prepared from lysogenic M. arthritidis bacteriophage MAV1, while DNA from low-virulence strains did not. One of the low-virulence strains, 158, was experimentally lysogenized with MAV1. Lysogenized 158 showed a significant increase in arthritogenicity over nonlysogenized 158. These data suggest that MAV1 carries a factor that is important in pathogenesis of M. arthritidis-induced arthritis of rats.

MeSH Terms
Animals Arthritis, Infectious/etiology Bacteriophages/genetics,pathogenicity DNA, Viral/analysis Lysogeny Male Mycoplasma/pathogenicity,virology Nucleic Acid Hybridization Rats Rats, Inbred Lew Virulence
Chemicals
DNA, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Voelker L L
Department of Microbiology, University of South Dakota School of Medicine, Vermillion 57069-2390, USA.
Weaver K E
Ehle L J
Washburn L R
References (31)
31 references, click to expand
  1. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. I. Induction of disease and histopathological characteristics.
    Infect Immun. 1971 Oct;4(4):344-55 PMID: 5154887
  2. Chronic arthritis of rabbits induced by mycoplasmas. I. Clinical microbiologic, and histologic features.
    Arthritis Rheum. 1980 Jul;23(7):825-36 PMID: 6996688
  3. Immunological responses of the rat to Mycoplasma arthritidis.
    J Bacteriol. 1969 Jun;98(3):930-7 PMID: 5305935
  4. The susceptibility of pleuropneumonia-like organisms to the in vitro action of antibiotics: aureomycin, chloramphenicol, dihydrostreptomycin, streptomycin, and sodium penicillin G.
    J Urol. 1950 Jul;64(1):167-73 PMID: 15429177
  5. THE SEROLOGICAL DIFFERENTIATION OF MYCOPLASMA STRAINS (PLEURO-PNEUMONIA-LIKE ORGANISMS) FROM VARIOUS SOURCES.
    J Hyg (Lond). 1964 Jun;62:199-219 PMID: 14171271
  6. Identification and characterization of IS1138, a transposable element from Mycoplasma pulmonis that belongs to the IS3 family.
    Mol Microbiol. 1993 Feb;7(4):577-84 PMID: 8096321
  7. Mechanisms of attachment of Mycoplasma arthritidis to host cells in vitro.
    Infect Immun. 1993 Jun;61(6):2670-80 PMID: 8500906
  8. Some characteristics of mycoplasma virus Hr 1, isolated from and infecting Mycoplasma hyorhinis. Brief report.
    Arch Virol. 1983;77(1):81-5 PMID: 6625888
  9. Experimental polyarthritis in rats produced by Mycoplasma arthritidis.
    J Comp Pathol. 1975 Jan;85(1):45-52 PMID: 1092737
  10. Isolation of a second cryptic plasmid from Mycoplasma mycoides subsp. mycoides.
    Plasmid. 1990 Sep;24(2):153-5 PMID: 2096401
  11. BIOCHEMICAL, MORPHOLOGICAL, AND SEROLOGICAL CHARACTERIZATION OF MYCOPLASMA OF MURINE ORIGIN.
    J Infect Dis. 1965 Apr;115:171-85 PMID: 14308364
  12. [Clinical and histopathological findings in mycoplasmal polyarthritis of rats. I. Course of infection during the first 8 days (author's transl)].
    Zentralbl Bakteriol Orig A. 1975;230(3):385-97 PMID: 1146445
  13. Role of organisms of the pleuropneumonia group in human genital infections.
    Br J Vener Dis. 1953 Sep;29(3):141-50 PMID: 13094008
  14. Effect of Animal Passage on Arthritogenic and Biological Properties of Mycoplasma arthritidis.
    Infect Immun. 1970 Jun;1(6):538-45 PMID: 16557773
  15. The Mycoplasma arthritidis T-cell mitogen, MAM: a model superantigen.
    Immunol Today. 1991 Aug;12(8):271-6 PMID: 1910449
  16. Comparison of four Mycoplasma arthritidis strains by enzyme immunoassay, metabolism inhibition, one- and two-dimensional electrophoresis, and immunoblotting.
    J Clin Microbiol. 1990 Sep;28(9):1974-81 PMID: 2229380
  17. Immunofluorescence identification of Mycoplasma on agar by use of incident illumination.
    J Bacteriol. 1967 Apr;93(4):1205-9 PMID: 5340303
  18. Comparison of Mycoplasma arthritidis strains by enzyme-linked immunosorbent assay, immunoblotting, and DNA restriction analysis.
    J Clin Microbiol. 1995 Sep;33(9):2271-9 PMID: 7494014
  19. Isolation of a virus from Mycoplasma pulmonis.
    Isr J Med Sci. 1987 May;23(5):418-22 PMID: 3667218
  20. Reproducible polyarthritis in rats caused by Mycoplasma arthritidis.
    Ann Rheum Dis. 1971 May;30(3):316-21 PMID: 5090248
  21. Genetic analysis of extracellular toxins of Staphylococcus aureus.
    Annu Rev Microbiol. 1989;43:375-402 PMID: 2679358
  22. Identification of an insertion-sequence-like genetic element in the newly recognized human pathogen Mycoplasma incognitus.
    Gene. 1990 Sep 1;93(1):67-72 PMID: 2172089
  23. Immunomodulation in vivo by the Mycoplasma arthritidis superantigen, MAM.
    Clin Infect Dis. 1993 Aug;17 Suppl 1:S163-9 PMID: 8399909
  24. A comparative study on the virulence of Mycoplasma arthritidis and "Mycoplasma hominis, type 2" strains in rats.
    Proc Soc Exp Biol Med. 1967 Jan;124(1):103-7 PMID: 6017752
  25. Vaccination of Lewis rats against Mycoplasma arthritidis-induced arthritis.
    Am J Vet Res. 1992 Jan;53(1):52-8 PMID: 1539916
  26. Experimental induction of arthritis in LEW rats and antibody response to four Mycoplasma arthritidis strains.
    Vet Microbiol. 1989 Nov;21(1):41-55 PMID: 2623796
  27. Natural mycoplasmal infections in isolator-maintained LEW/Tru rats.
    Lab Anim Sci. 1988 Aug;38(4):381-8 PMID: 3263542
  28. Interaction of Mycoplasma arthritidis and other mycoplasmas with murine peritoneal macrophages.
    Infect Immun. 1973 May;7(5):691-9 PMID: 4587519
  29. [Factors influencing the susceptibility of mice to Mycoplasma arthritidis].
    Infect Immun. 1973 Feb;7(2):218-25 PMID: 4572611
  30. Isolation and restriction endonuclease analysis of a mycoplasma plasmid.
    Plasmid. 1988 Jan;19(1):68-70 PMID: 2840682
  31. A Mycoplasma genetic element resembling prokaryotic insertion sequences.
    Mol Microbiol. 1989 Jul;3(7):957-67 PMID: 2552257
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.63.10.4016-4023.1995
Published
1995-10-00
Pages
4016-23
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC173564
Subset
IM
Grants
PHS HHS · R01 37924 · United States
External Links
PubMed source DOI: 10.1128/iai.63.10.4016-4023.1995 PMC Full Text View journal details
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