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PMID: 7568165 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

G protein activation kinetics and spillover of gamma-aminobutyric acid may account for differences between inhibitory responses in the hippocampus and thalamus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 92 ·No. 21 ·1995-10-10 ·Pages 9515-9

Destexhe A, Sejnowski TJ

Abstract

We have developed a model of gamma-aminobutyric acid (GABA)ergic synaptic transmission mediated by GABAA and GABAB receptors, including cooperativity in the guanine nucleotide binding protein (G protein) cascade mediating the activation of K+ channels by GABAB receptors. If the binding of several G proteins is needed to activate the K+ channels, then only a prolonged activation of GABAB receptors evoked detectable currents. This could occur if strong stimuli evoked release in adjacent terminals and the spillover resulted in prolonged activation of the receptors, leading to inhibitory responses similar to those observed in hippocampal slices. The same model also reproduced thalamic GABAB responses to high-frequency bursts of stimuli. In this case, prolonged activation of the receptors was due to high-frequency release conditions. This model provides insights into the function of GABAB receptors in normal and epileptic discharges.

MeSH Terms
GTP-Binding Proteins/metabolism Hippocampus/physiology Models, Neurological Neural Inhibition/physiology Potassium Channels/metabolism Receptors, GABA-B/metabolism Signal Transduction Synaptic Transmission Thalamus/physiology gamma-Aminobutyric Acid/metabolism
Chemicals
Potassium Channels Receptors, GABA-B gamma-Aminobutyric Acid GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Destexhe A
Howard Hughes Medical Institute, Salk Institute for Biological Studies, Computational Neurobiology Laboratory, La Jolla, CA 92037, USA.
Sejnowski T J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.92.21.9515
Published
1995-10-10
Pages
9515-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC40832
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.92.21.9515 PMC Full Text View journal details
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