Abstract
We have cloned and sequenced a 1.9 kb fragment of the 5'-upstream sequence of the smooth-muscle-specific gene SM22 alpha. The region cloned consisted of the SM22 alpha promoter, a 65 bp exon containing most of the 5'-untranslated region and 307 bp of the first intron. A 1.5 kb fragment at the 5' end of this sequence was able to drive the expression of a reporter chloramphenicol acetyltransferase (CAT) gene in both vascular smooth-muscle cells and Rat-1 fibroblasts. This promoter region did not contain a consensus TATAA box but contained the sequence TTTAAA 25 bp from the major start site identified by primer extension. Deletion analysis showed that a fragment of the promoter from +65 to -303 was more active in both cell types than the 1.5 kb fragment suggesting that there are silencer sequences in the region 5' to the core promoter. CAT activity was also observed with fragments containing bases +65 to -193 and +65 to -117 in smooth-muscle cells. In contrast with the smooth-muscle cells, no CAT activity was detected in Rat-1 fibroblasts with the smallest two fragments. The residual promoter activity in the smallest fragment of the SM22 alpha promoter tested suggested that, unlike the smooth-muscle alpha-actin promoter, transcription from the SM22 alpha promoter can occur in smooth-muscle cells in the absence of factors binding to CC(A/Trich)6GG (CArG box) or CANNTG (E box) motifs.
MeSH Terms
Animals
Base Sequence
Binding Sites
Blotting, Northern
Cell Line
Cells, Cultured
Chloramphenicol O-Acetyltransferase/biosynthesis
Cloning, Molecular
Consensus Sequence
DNA Primers
DNA-Binding Proteins/metabolism
Exons
Genomic Library
Introns
Microfilament Proteins
Molecular Sequence Data
Muscle Proteins/biosynthesis,genetics
Muscle, Smooth, Vascular/metabolism
Polymerase Chain Reaction
Promoter Regions, Genetic
RNA, Messenger/analysis,biosynthesis
Rats/genetics
Recombinant Proteins/biosynthesis
Restriction Mapping
Sequence Deletion
TATA Box
Transcription, Genetic
Transfection
Chemicals
DNA Primers
DNA-Binding Proteins
Microfilament Proteins
Muscle Proteins
RNA, Messenger
Recombinant Proteins
Tagln protein, mouse
transgelin
Chloramphenicol O-Acetyltransferase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Kemp P R
Department of Biochemistry, Cambridge University, U.K.
Osbourn J K
Grainger D J
Metcalfe J C
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