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PMID: 7583140
Published · ppublish
English
Journal Article
Review
Proteolysis. The proteasome: a protein-degrading organelle?
Abstract
The crystal structure of the proteasome suggests that degradation of ubiquitin-protein conjugates is achieved by unfolding the protein substrate and translocating it through a channel into a peptidase-containing chamber.
MeSH Terms
Biological Transport
Cysteine Endopeptidases/chemistry,metabolism
Hydrolysis
Multienzyme Complexes/chemistry,metabolism
Organelles/metabolism
Proteasome Endopeptidase Complex
Protein Conformation
Protein Folding
Proteins/metabolism
Saccharomyces cerevisiae/enzymology
Thermoplasma/enzymology
Ubiquitins/metabolism
Chemicals
Multienzyme Complexes
Proteins
Ubiquitins
Cysteine Endopeptidases
Proteasome Endopeptidase Complex
Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
Published
1995-08-01
Pages
854-8
Language
English
Region
England
NLM ID
9107782
Subset
IM
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