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PMID: 7594765 Published · ppublish English Journal Article Review

K-ras mutation and pancreatic adenocarcinoma.

International journal of pancreatology : official journal of the International Association of Pancreatology ·Vol. 18 ·No. 1 ·1995-08-00 ·Pages 1-6

Caldas C, Kern SE

Abstract

暂无摘要

MeSH Terms
Adenocarcinoma/genetics Genes, ras Humans Mutation Pancreatic Neoplasms/genetics Precancerous Conditions/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Caldas C
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kern S E
References (65)
65 references, click to expand
  1. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions.
    Cancer Res. 1994 Jun 1;54(11):3025-33 PMID: 8187092
  2. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice.
    Cell. 1987 Mar 27;48(6):1023-34 PMID: 3470144
  3. Frequent glycine-to-aspartic acid mutations at codon 12 of c-Ki-ras gene in human pancreatic cancer in Japanese.
    Jpn J Cancer Res. 1990 Feb;81(2):135-40 PMID: 2110130
  4. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.
    Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9141-5 PMID: 8090782
  5. Factors influencing survival after pancreaticoduodenectomy for pancreatic cancer.
    Am J Surg. 1991 Jan;161(1):120-4; discussion 124-5 PMID: 1987845
  6. Species-specific differences in tumorigenesis and senescence.
    Trends Genet. 1994 Sep;10(9):305-6 PMID: 7974742
  7. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma.
    Nat Genet. 1994 Sep;8(1):27-32 PMID: 7726912
  8. Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.
    Mol Carcinog. 1990;3(5):296-301 PMID: 2173932
  9. Identification of K-ras oncogene mutations in the pure pancreatic juice of patients with ductal pancreatic cancers.
    Jpn J Cancer Res. 1993 Sep;84(9):961-5 PMID: 8407563
  10. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.
    Cancer Res. 1994 Mar 15;54(6):1556-60 PMID: 8137263
  11. Relation of pancreatic duct hyperplasia to carcinoma.
    Cancer. 1979 Apr;43(4):1418-28 PMID: 445339
  12. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.
    Nucleic Acids Res. 1988 Aug 25;16(16):7773-82 PMID: 3047672
  13. Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.
    Cancer Res. 1991 Jul 1;51(13):3497-502 PMID: 1675933
  14. Pancreatic duct hyperplasia and cancer.
    Gastroenterology. 1954 Nov;27(5):629-40 PMID: 13210601
  15. Ki-ras mutations in pancreatic secretions and aspirates from two patients without pancreatic cancer.
    J Natl Cancer Inst. 1994 Oct 19;86(20):1547-9 PMID: 7932811
  16. A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides.
    Gene. 1986;50(1-3):313-20 PMID: 3582981
  17. Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization.
    Nucleic Acids Res. 1984 Dec 11;12(23):9155-63 PMID: 6595642
  18. Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.
    Cancer Res. 1993 Jun 1;53(11):2472-4 PMID: 8495407
  19. Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas.
    Oncogene. 1989 Sep;4(9):1137-40 PMID: 2674856
  20. A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells.
    Proc Natl Acad Sci U S A. 1985 Nov;82(22):7575-9 PMID: 2415964
  21. Allelotype of pancreatic adenocarcinoma.
    Cancer Res. 1994 May 15;54(10):2761-4 PMID: 8168108
  22. Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
    Am J Pathol. 1994 May;144(5):889-95 PMID: 8178941
  23. Molecular determinants of dysplasia in colorectal lesions.
    Cancer Res. 1994 Nov 1;54(21):5523-6 PMID: 7923189
  24. Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation.
    Cancer Res. 1993 Mar 1;53(5):953-6 PMID: 8439969
  25. Predisposition to neoplastic transformation caused by gene replacement of H-ras1.
    Science. 1993 Jun 4;260(5113):1524-7 PMID: 8502998
  26. Frequent somatic mutations of the APC gene in human pancreatic cancer.
    Cancer Res. 1992 Dec 1;52(23):6696-8 PMID: 1423316
  27. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras.
    Science. 1993 Apr 2;260(5104):85-8 PMID: 8465203
  28. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
    Cancer Res. 1994 Jul 1;54(13):3568-73 PMID: 8012983
  29. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes.
    Nature. 1982 Jul 22;298(5872):343-7 PMID: 6283384
  30. A genetic model for colorectal tumorigenesis.
    Cell. 1990 Jun 1;61(5):759-67 PMID: 2188735
  31. Clinical application of ras gene mutation for diagnosis of pancreatic adenocarcinoma.
    Gastroenterology. 1991 Jan;100(1):233-8 PMID: 1983826
  32. The ras gene family and human carcinogenesis.
    Mutat Res. 1988 May;195(3):255-71 PMID: 3283542
  33. Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis.
    Virchows Arch A Pathol Anat Histol. 1980;387(2):221-33 PMID: 7456311
  34. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor.
    Science. 1993 Jun 25;260(5116):1934-7 PMID: 8316833
  35. Morphological lesions associated with human primary invasive nonendocrine pancreas cancer.
    Cancer Res. 1976 Jul;36(7 PT 2):2690-8 PMID: 1277176
  36. Rapid and sensitive nonradioactive detection of mutant K-ras genes via 'enriched' PCR amplification.
    Oncogene. 1991 Jun;6(6):1079-83 PMID: 1676837
  37. K-ras mutations in putative preneoplastic lesions in human colon.
    J Natl Cancer Inst. 1993 Dec 15;85(24):2004-7 PMID: 8246286
  38. Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma.
    Ann Surg. 1993 Feb;217(2):138-43 PMID: 8439212
  39. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.
    Cell. 1988 May 20;53(4):549-54 PMID: 2453289
  40. Soluble normal and mutated DNA sequences from single-copy genes in human blood.
    Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):67-71 PMID: 8118388
  41. Activation of the c-K-ras oncogene in a human pancreas carcinoma.
    Biochem Biophys Res Commun. 1985 Feb 28;127(1):168-74 PMID: 3855240
  42. Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas.
    Cancer Res. 1990 Feb 15;50(4):1279-83 PMID: 2404591
  43. Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
    Science. 1992 Apr 3;256(5053):102-5 PMID: 1566048
  44. The clonal evolution of tumor cell populations.
    Science. 1976 Oct 1;194(4260):23-8 PMID: 959840
  45. High frequency of Ki-ras codon 12 mutations in pancreatic adenocarcinomas.
    Int J Cancer. 1989 Jun 15;43(6):1037-41 PMID: 2659539
  46. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
    Am J Pathol. 1993 Aug;143(2):545-54 PMID: 8342602
  47. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.
    Science. 1993 Jun 25;260(5116):1937-42 PMID: 8316834
  48. K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
    Cancer Res. 1992 Aug 15;52(16):4507-13 PMID: 1643642
  49. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.
    Cancer Res. 1993 Nov 1;53(21):5087-9 PMID: 8221640
  50. Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases.
    Cancer. 1991 Feb 1;67(3):634-7 PMID: 1845953
  51. Inactivation of both APC alleles in human and mouse tumors.
    Cancer Res. 1994 Nov 15;54(22):5953-8 PMID: 7954428
  52. K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer.
    J Natl Cancer Inst. 1993 Dec 15;85(24):1978-80 PMID: 8246279
  53. Detection of c-Ki-ras mutation by PCR/RFLP analysis and diagnosis of pancreatic adenocarcinomas.
    J Natl Cancer Inst. 1993 Dec 15;85(24):2008-12 PMID: 7902444
  54. Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene.
    Ann Surg. 1991 Dec;214(6):657-62 PMID: 1741644
  55. Clonality: more than just a tumor-progression model.
    J Natl Cancer Inst. 1993 Jul 7;85(13):1020-1 PMID: 8515481
  56. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.
    Proc Natl Acad Sci U S A. 1982 Jun;79(11):3637-40 PMID: 6285355
  57. c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas.
    Jpn J Cancer Res. 1991 Oct;82(10):1057-60 PMID: 1955373
  58. ras oncogenes in human cancer: a review.
    Cancer Res. 1989 Sep 1;49(17):4682-9 PMID: 2547513
  59. PCR-based approaches for detection of mutated ras genes.
    PCR Methods Appl. 1992 May;1(4):211-6 PMID: 1362126
  60. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.
    Nature. 1982 Nov 11;300(5888):149-52 PMID: 7133135
  61. Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
    Oncogene. 1991 May;6(5):857-62 PMID: 1646989
  62. Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma.
    Cancer Res. 1992 May 1;52(9):2616-9 PMID: 1314700
  63. Frequency and types of point mutation at the 12th codon of the c-Ki-ras gene found in pancreatic cancers from Japanese patients.
    Jpn J Cancer Res. 1989 Jul;80(7):622-6 PMID: 2507485
  64. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.
    Nature. 1982 Jun 10;297(5866):474-8 PMID: 6283357
  65. Pancreatic carcinoma.
    N Engl J Med. 1992 Feb 13;326(7):455-65 PMID: 1732772
Article Info
Journal
International journal of pancreatology : official journal of the International Association of Pancreatology
Abbr.
Int J Pancreatol
ISSN
0169-4197
DOI
10.1007/BF02825415
Published
1995-08-00
Pages
1-6
Language
English
Region
United States
NLM ID
8703511
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02825415
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