T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.
Interleukin-2 (IL-2)-deficient (IL-2-/-) mice develop anemia and colonic inflammatory bowel disease. To elucidate the mechanism of this disease, we have bred IL-2-/- mice to two strains of immunodeficient mice, RAG-2-deficient (RAG-2-/-, lacking B and T cells) and JH-deficient mice (JH-/-, lacking B cells). IL-2-/-, RAG-2-/- double-mutant mice are disease free, while IL-2-/-, JH-/- double-mutant mice succumb to bowel disease at the same rate as IL-2-/- littermates. IL-2-/-, JH-/- mice do not, however, succumb to anemia. Thus, spontaneous intestinal inflammation in IL-2-/- mice requires mature T cells, not B cells, while anemia is dependent on B cells.
14 references, click to expand
-
Interleukin-10-deficient mice develop chronic enterocolitis.Cell. 1993 Oct 22;75(2):263-74 PMID: 8402911
-
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice.Cell. 1993 Oct 22;75(2):274-82 PMID: 8104709
-
Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice.Int Immunol. 1993 Nov;5(11):1461-71 PMID: 7903159
-
The role of B cells in lpr/lpr-induced autoimmunity.J Exp Med. 1994 Oct 1;180(4):1295-306 PMID: 7931063
-
Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice.Gastroenterology. 1994 Dec;107(6):1643-52 PMID: 7958674
-
Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.Immunity. 1995 Mar;2(3):223-38 PMID: 7697543
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.Cell. 1993 Oct 22;75(2):253-61 PMID: 8402910
-
A new surface antigen on intraepithelial lymphocytes in the intestine.Eur J Immunol. 1990 Oct;20(10):2201-7 PMID: 2242756
-
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.Nature. 1991 Aug 15;352(6336):621-4 PMID: 1830926
-
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.Cell. 1992 Mar 6;68(5):855-67 PMID: 1547487
-
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity.Cell. 1993 Feb 26;72(4):551-60 PMID: 7679952
-
Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus.Int Immunol. 1993 Jun;5(6):647-56 PMID: 8347558
-
Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice.Cell. 1993 Oct 22;75(2):203-5 PMID: 8402907
-
CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria.J Immunol. 1988 Nov 1;141(9):3029-36 PMID: 2902143
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
