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PMID: 7600292 Published · ppublish English Journal Article

Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms.

Immunity ·Vol. 1 ·No. 8 ·1994-11-00 ·Pages 647-59

Weinstein PD, Anderson AO, Mage RG

Abstract

Although the rabbit IgH locus contains approximately 100 VH genes, the majority of B cells rearrange VH1. To produce a primary repertoire containing a sufficient number of protective antibodies, rearranged VH1-DH-JH sequences may diversify within rabbit B cells in an organ that functions like a chicken bursa, sheep ileal Peyer's patch, or both. It was suggested many years ago that the rabbit appendix could be a bursal equivalent. To reexamine this possibility, we analyzed rearranged heavy chain variable region sequences in B cells from light and dark zones of appendix germinal centers from 6-week-old rabbits. Our findings indicate that antibody diversification occurs by gene conversion-like and somatic hypermutation mechanisms in appendix germinal centers of young rabbits.

MeSH Terms
Amino Acid Sequence Animals Antibody Diversity Antibody Formation Appendix/cytology,physiology B-Lymphocytes/metabolism Base Sequence Cloning, Molecular Gene Conversion Gene Rearrangement, B-Lymphocyte, Heavy Chain Genes, Immunoglobulin Lymphoid Tissue/physiology Models, Genetic Molecular Sequence Data Mutation Polymerase Chain Reaction Rabbits Sequence Alignment Sequence Analysis, DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Weinstein P D
Applied Research Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA.
Anderson A O
Mage R G
Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1074-7613
DOI
10.1016/1074-7613(94)90036-1
Published
1994-11-00
Pages
647-59
Language
English
Region
United States
NLM ID
9432918
Subset
IM
Databases
GENBANK
U07070, U07071, U07072, U07073, U07074, U07075, U07076, U07077, U07078, U07079, U07080, U07081, U07082, U07109, U07110, U07111, U07112, U07113, U07114, U07115, U07116, U07117, U07118, U07119, U07120, U07121, U07122, U07123, U07124, U07125
External Links
PubMed source DOI: 10.1016/1074-7613(94)90036-1 View journal details
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