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PMID: 7604284 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Comment

Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein.

Science (New York, N.Y.) ·Vol. 269 ·No. 5220 ·1995-07-07 ·Pages 86-9

Bookbinder LH, Cheng A, Bleil JD

Abstract

Mouse sperm recognize and bind to ZP3, one of three glycoproteins in the egg's zona pellucida. A mouse sperm protein, sp56, was identified that has the characteristics expected of the sperm protein responsible for recognition of ZP3. The complementary DNA encoding sp56 was isolated, and its primary sequence indicates that sp56 is a member of a superfamily of protein receptors. It was shown that sp56 expression is restricted to mouse spermatids and that the presence or absence of sp56 on sperm from different species accounts for species specificity of sperm-egg recognition in mice.

MeSH Terms
Amino Acid Sequence Animals Cricetinae Egg Proteins/metabolism Female Guinea Pigs Humans Male Membrane Glycoproteins/metabolism Mice Molecular Sequence Data Molecular Weight Organ Specificity RNA, Messenger/analysis,genetics Receptors, Cell Surface/biosynthesis,chemistry,genetics,metabolism Species Specificity Sperm-Ovum Interactions/physiology Spermatids/metabolism Spermatozoa/metabolism Zona Pellucida/metabolism Zona Pellucida Glycoproteins
Chemicals
Egg Proteins Membrane Glycoproteins RNA, Messenger Receptors, Cell Surface ZP3 protein, human Zona Pellucida Glycoproteins Zp3 protein, mouse sp56 protein, mouse
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bookbinder L H
Scripps Research Institute, Department of Molecular Biology, La Jolla, CA 92037, USA.
Cheng A
Bleil J D
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.7604284
Published
1995-07-07
Pages
86-9
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NICHD NIH HHS · R01 HD 27847 · United States
Databases
GENBANK
U17108
Corrections
ErratumIn
-
CommentIn
PMID: 7604276
CommentOn
PMID: 7604276
External Links
PubMed source DOI: 10.1126/science.7604284 View journal details
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