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PMID: 7607293 Published · ppublish English Journal Article Review

Nitric oxide: a synchronizing chemical messenger.

Experientia ·Vol. 51 ·No. 6 ·1995-06-14 ·Pages 545-50

Anbar M

Abstract

Nitric oxide (NO) has been recognized as a ubiquitous chemical messenger in a large number of different biological systems. Its chemical properties make it less specific and less controllable than practically any other neurotransmitter or hormone. In view of this, its extensive biological role as a chemical messenger seems surprising. It is suggested that the biological function of NO evolved early in the anaerobic stage of evolution. In view of its low molecular weight, limited interaction with water, and its electrical neutrality, which allow it to diffuse rapidly through the cytoplasm and biomembranes, it is suggested that the need for NO has been retained by and maintained in eukaryote cells because of its ability to affect many biochemical functions simultaneously, acting primarily as an intracellular synchronizing chemical messenger.

MeSH Terms
Animals Humans Nitric Oxide/metabolism Signal Transduction
Chemicals
Nitric Oxide
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Anbar M
Department of Biophysical Sciences, School of Medicine and Biomedical Sciences, SUNY, Buffalo 14214, USA.
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF02128740
Published
1995-06-14
Pages
545-50
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02128740
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