Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13.

Human genetics ·Vol. 96 ·No. 1 ·1995-07-00 ·Pages 99-101

Zhou J, Neidigh JL, Espinosa R, LeBeau MM, McClain DA

Abstract

It has been previously shown that some toxic effects of high concentrations of glucose are mediated by the hexosamine biosynthesis pathway and its rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFA). We have used the cloned human GFA cDNA to study the chromosomal localization of the gene and tissue distribution of mRNA. The human GFA gene is on chromosome 2, band p13 as determined by fluorescence in situ hybridization. An 8-kb species of GFA mRNA was detected in all rat tissues tested with relatively high expression in testis and smooth muscle; a unique 3-kb mRNA species was found only in testis.

MeSH Terms

Animals Chromosomes, Human, Pair 2/genetics Gene Expression/genetics Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)/genetics Humans In Situ Hybridization RNA, Messenger/genetics Rats

Chemicals

RNA, Messenger Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Zhou J

Veterans Administration Medical Center, Jackson, MS 39216, USA.

Neidigh J L

Espinosa R

LeBeau M M

McClain D A

References (8)

8 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00214194

Published

1995-07-00

Pages

99-101

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00214194 View journal details

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Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13.

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