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PMID: 76166 Published · ppublish English Case Reports Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

Prevention by bedtime cimetidine of duodenal-ulcer relapse.

Lancet (London, England) ·Vol. 1 ·No. 8065 ·1978-03-25 ·Pages 626-7

Blackwood WS, Maudgal DP, Northfield TC

Abstract

45 patients with healed duodenal ulcers completed a six-month double-blind trial to compare the effects of cimetidine and placebo on the prevention of duodenal-ulcer relapse. A single bedtime dose of cimetidine (800 mg) was given and ulcer relapse was assessed endoscopically at regular intervals. At the end of the six-month trial, 16 of the 21 (76%) cimetidine-treated patients remained ulcer-free compared with only 3 of the 24 (12.5%) placebo-treated patients. No untoward effects of this treatment were observed.

MeSH Terms

Adult Child Cimetidine/administration & dosage,therapeutic use Clinical Trials as Topic Double-Blind Method Drug Evaluation Duodenal Ulcer/prevention & control Female Follow-Up Studies Guanidines/administration & dosage Humans In Vitro Techniques Infant Male Middle Aged Placebos Recurrence Time Factors

Chemicals

Guanidines Placebos Cimetidine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Blackwood W S

Maudgal D P

Northfield T C

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(78)91135-2

Published

1978-03-25

Pages

626-7

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(78)91135-2 View journal details

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Prevention by bedtime cimetidine of duodenal-ulcer relapse.

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