The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat.

Psychopharmacology ·Vol. 118 ·No. 2 ·1995-03-00 ·Pages 230-2

Bristow LJ, Landon L, Saywell KL, Tricklebank MD

Abstract

Previous studies have demonstrated that the glycine/NMDA receptor antagonist, L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)quinolone) blocks the activation of mesolimbic dopamine systems induced following psychostimulant administration in the rat (Bristow et al. 1994). In the present study, pretreatment with L-701,324 also reversed the deficit in prepulse inhibition (PPI) observed in rats reared in social isolation after weaning. Given that PPI is also attenuated in schizophrenic patients and that isolation rearing induces both neurochemical and behavioural abnormalities suggestive of a physiologically induced state of dopaminergic hyperactivity, these results suggest that blockade of the glycine/NMDA receptor may offer a new strategy for the development of novel antipsychotic agents.

MeSH Terms

Acoustic Stimulation Animals Dose-Response Relationship, Drug Male Quinolones/pharmacology Rats Receptors, Glycine/antagonists & inhibitors Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors Reflex, Startle/drug effects Social Isolation

Chemicals

Quinolones Receptors, Glycine Receptors, N-Methyl-D-Aspartate L 701324

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bristow L J

Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.

Landon L

Saywell K L

Tricklebank M D

References (11)

11 references, click to expand

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Article Info

Journal

Psychopharmacology

Abbr.

Psychopharmacology (Berl)

ISSN

0033-3158

DOI

10.1007/BF02245847

Published

1995-03-00

Pages

230-2

Language

English

Region

Germany

NLM ID

7608025

Subset

External Links

PubMed source DOI: 10.1007/BF02245847 View journal details

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The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat.

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