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PMID: 7647594 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Myocardial regeneration. Transplanting satellite cells into damaged myocardium.

Texas Heart Institute journal ·Vol. 22 ·No. 2 ·1995-00-00 ·Pages 119-25

Yoon PD, Kao RL, Magovern GJ

Abstract

Millions of Americans suffer from chronic heart failure. Despite treatments with heart transplantation, cardiomyoplasty, and artificial assist devices, an ideal therapy is yet to be found. Since 1988, we have studied the transplantation of myogenic stem cells from skeletal muscle into injured myocardium in the hope that these cells would multiply and differentiate, thereby improving the function of the failing heart. We have achieved 2 goals thus far: the 1st was improving the culture technique to obtain high yield and purity of the satellite cells; the 2nd was successfully implanting cultured satellite cells in dog hearts and later identifying them as new myocardium. We share our findings here to encourage more study in this promising area.

MeSH Terms
Animals Cell Differentiation/physiology Cell Survival/physiology Cells, Cultured Dogs Heart Failure/pathology,surgery Heart Transplantation/pathology Muscle, Skeletal/pathology,transplantation Myocardium/pathology Regeneration/physiology Stem Cell Transplantation Stem Cells/pathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yoon P D
Cardiothoracic Surgical Research, Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, USA.
Kao R L
Magovern G J
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21 references, click to expand
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Article Info
Journal
Texas Heart Institute journal
Abbr.
Tex Heart Inst J
ISSN
0730-2347
Published
1995-00-00
Pages
119-25
Language
English
Region
United States
NLM ID
8214622
PMCID
PMC325230
Subset
IM
Grants
NHLBI NIH HHS · HL 54286 · United States
External Links
PubMed source PMC Full Text View journal details
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