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PMID: 7667636 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

CDC25 phosphatases as potential human oncogenes.

Science (New York, N.Y.) ·Vol. 269 ·No. 5230 ·1995-09-15 ·Pages 1575-7

Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M, Beach D

Abstract

Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either Ha-RASG12V or loss of RB1 in oncogenic focus formation. Such transformants were highly aneuploid, grew in soft agar, and formed high-grade tumors in nude mice. Overexpression of CDC25B was detected in 32 percent of human primary breast cancers tested. The CDC25 phosphatases may contribute to the development of human cancer.

Related Genes
CDC25A CDC25B CDC25C H-ras RB1 p53
MeSH Terms
Animals Breast Neoplasms/genetics Cell Cycle Proteins/genetics Cell Division Cell Transformation, Neoplastic Cells, Cultured Gene Expression Genes, Retinoblastoma Genes, p53 Genes, ras Humans In Situ Hybridization Mice Mice, Inbred BALB C Mice, Nude Multigene Family Neoplasm Transplantation Oncogenes Phosphoprotein Phosphatases/genetics Prognosis Transfection Tumor Cells, Cultured cdc25 Phosphatases
Chemicals
Cell Cycle Proteins Phosphoprotein Phosphatases CDC25C protein, human Cdc25c protein, mouse cdc25 Phosphatases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Galaktionov K
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, NY 11724, USA.
Lee A K
Eckstein J
Draetta G
Meckler J
Loda M
Beach D
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.7667636
Published
1995-09-15
Pages
1575-7
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.7667636 View journal details
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