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PMID: 7671310 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

Cell ·Vol. 82 ·No. 5 ·1995-09-08 ·Pages 823-9

Greenwell PW, Kronmal SL, Porter SE, Gassenhuber J, Obermaier B, Petes TD

Abstract

Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectasia gene.

Related Genes

ATM TEL1 mec1 tor1 tor2

MeSH Terms

Chromosomes/genetics,radiation effects Cloning, Molecular Genes, Fungal/genetics Humans Mitosis/genetics,radiation effects Molecular Sequence Data Mutation/radiation effects Saccharomyces cerevisiae/genetics Sequence Homology, Amino Acid Telomere/genetics

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Greenwell P W

Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.

Kronmal S L

Porter S E

Gassenhuber J

Obermaier B

Petes T D

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/0092-8674(95)90479-4

Published

1995-09-08

Pages

823-9

Language

English

Region

United States

NLM ID

0413066

Subset

Grants

NIGMS NIH HHS · GM24110 · United States

NIGMS NIH HHS · GM52319 · United States

Databases

GENBANK

U31331

External Links

PubMed source DOI: 10.1016/0092-8674(95)90479-4 View journal details

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TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

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