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PMID: 7680492 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis.

Science (New York, N.Y.) ·Vol. 259 ·No. 5099 ·1993-02-26 ·Pages 1318-20

Miyata T, Takeda J, Iida Y, Yamada N, Inoue N, Takahashi M, Maeda K, Kitani T, Kinoshita T

Abstract

The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.

Related Genes
PIG-A
MeSH Terms
Amino Acid Sequence Animals Antigens, CD/metabolism Antigens, Surface/metabolism CD55 Antigens CD59 Antigens Cloning, Molecular DNA/genetics Genetic Complementation Test Glycosylphosphatidylinositols/biosynthesis HeLa Cells Humans In Vitro Techniques Membrane Glycoproteins/metabolism Membrane Proteins/genetics,metabolism Mice Molecular Sequence Data Solubility Species Specificity Thy-1 Antigens
Chemicals
Antigens, CD Antigens, Surface CD55 Antigens CD59 Antigens Glycosylphosphatidylinositols Membrane Glycoproteins Membrane Proteins Thy-1 Antigens phosphatidylinositol glycan-class A protein DNA
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Miyata T
Department of Immunoregulation, Osaka University, Japan.
Takeda J
Iida Y
Yamada N
Inoue N
Takahashi M
Maeda K
Kitani T
Kinoshita T
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.7680492
Published
1993-02-26
Pages
1318-20
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Databases
GENBANK
D11466
External Links
PubMed source DOI: 10.1126/science.7680492 View journal details
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