The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes.

Current opinion in immunology ·Vol. 5 ·No. 3 ·1993-06-00 ·Pages 341-8

Fearon DT

Abstract

A paradigm describing the response of T lymphocytes to antigen holds that signals from antigen receptors must be modulated by non-antigen-specific, accessory membrane proteins for an appropriate cellular response to occur, such as differentiation, activation and tolerance. Recent studies suggest that this paradigm applies also to B lymphocytes. Signaling through membrane IgM in these cells requires CD45, a phosphotyrosine phosphatase, and is amplified by a complex containing CD19, complement receptor 2 (CD21), and TAPA-1, which recruits the intracellular enzyme, phosphatidylinositol 3-kinase.

MeSH Terms

Animals Antigens, CD/physiology Antigens, CD19 Antigens, Differentiation, B-Lymphocyte/physiology Antigens, Surface/physiology B-Lymphocytes/immunology Guinea Pigs Humans Immunoglobulin M/immunology Leukocyte Common Antigens/physiology Ligands Lymphocyte Activation/physiology Macromolecular Substances Membrane Proteins Mice Models, Biological Multigene Family Phosphorylation Protein Processing, Post-Translational Protein-Tyrosine Kinases/physiology Receptors, Antigen, B-Cell/physiology Receptors, Complement 3d/physiology Signal Transduction/physiology Tetraspanin 28

Chemicals

Antigens, CD Antigens, CD19 Antigens, Differentiation, B-Lymphocyte Antigens, Surface CD81 protein, human Cd81 protein, mouse Immunoglobulin M Ligands Macromolecular Substances Membrane Proteins Receptors, Antigen, B-Cell Receptors, Complement 3d Tetraspanin 28 Protein-Tyrosine Kinases Leukocyte Common Antigens

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Fearon D T

University of Cambridge School of Clinical Medicine, UK.

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/0952-7915(93)90051-s

Published

1993-06-00

Pages

341-8

Language

English

Region

England

NLM ID

8900118

Subset

External Links

PubMed source DOI: 10.1016/0952-7915(93)90051-s View journal details

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The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes.

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