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PMID: 7701046 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The atypical antipsychotic, remoxipride, blocks phencyclidine-induced disruption of prepulse inhibition in the rat.

Psychopharmacology ·Vol. 116 ·No. 4 ·1994-12-00 ·Pages 437-42

Johansson C, Jackson DM, Svensson L

Abstract

The effect of various typical (haloperidol) and atypical (clozapine, raclopride, remoxipride) antipsychotics on phencyclidine (PCP)-induced disruption of sensorimotor gating was tested in rats using an acoustic startle paradigm. Clozapine (4-40 mumol/kg), haloperidol (1-5 mumol/kg) and raclopride (1-12 mumol/kg) failed to reverse PCP-induced disruption of prepulse inhibition (PPI) of the acoustic startle response. In contrast, remoxipride (12-60 mumol/kg) caused a dose-dependent block of this effect. PCP-induced disruption of PPI is a widely accepted animal model of a corresponding behavioural deficit observed in schizophrenia although little evidence has been presented that it is in fact sensitive to antipsychotic agents. The present results indicate that remoxipride behaves in a unique way in this model compared to clozapine, haloperidol and raclopride.

MeSH Terms
Acoustic Stimulation Animals Antipsychotic Agents/pharmacology Clozapine/pharmacology Dopamine Agonists/pharmacology Dose-Response Relationship, Drug Haloperidol/pharmacology Male Phencyclidine/antagonists & inhibitors,pharmacology Raclopride Rats Rats, Sprague-Dawley Reflex, Startle/drug effects Remoxipride/pharmacology Salicylamides/pharmacology
Chemicals
Antipsychotic Agents Dopamine Agonists Salicylamides Remoxipride Raclopride Phencyclidine Clozapine Haloperidol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Johansson C
Astra Arcus AB, Södertälje, Sweden.
Jackson D M
Svensson L
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF02247475
Published
1994-12-00
Pages
437-42
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02247475 View journal details
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