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PMID: 7706460 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of four chromosomal loci determining obesity in a multifactorial mouse model.

The Journal of clinical investigation ·Vol. 95 ·No. 4 ·1995-04-00 ·Pages 1545-52

Warden CH, Fisler JS, Shoemaker SM, Wen PZ, Svenson KL, Pace MJ, Lusis AJ

Abstract

We previously described a new mouse model for multigenic obesity, designated BSB. We now report the use of a complete linkage map approach to identify loci contributing to body fat and other traits associated with obesity in this model. Four loci exhibiting linkage with body fat, or with the weights of four different fat depots, residing on mouse chromosomes 6, 7, 12, and 15, were identified and confirmed by analysis of additional BSB mice. Each of the four loci differed with respect to their effects on the percent of body fat, specific fat depots and plasma lipoproteins. The loci exhibited allele-specific, non-additive interactions. A locus for hepatic lipase activity was co-incident with the body fat and total cholesterol loci on chromosome 7, providing a possible mechanism linking plasma lipoproteins and obesity. The chromosome 7 locus affecting body fat, total cholesterol and hepatic lipase activity was isolated in congenic strains whose donor strain regions overlap with the chromosome 7 BSB locus. These results provide candidate genes and candidate loci for the analysis of human obesity.

MeSH Terms
Adipose Tissue Animals Body Constitution Causality Cholesterol/analysis Chromosome Mapping Crosses, Genetic Disease Models, Animal Female Genetic Linkage Genotype Lipoproteins/analysis Lod Score Male Mice/genetics Mice, Inbred C57BL Muridae Obesity/genetics Phenotype
Chemicals
Lipoproteins Cholesterol
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Warden C H
Department of Medicine, University of California, Los Angeles 90095, USA.
Fisler J S
Shoemaker S M
Wen P Z
Svenson K L
Pace M J
Lusis A J
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI117827
Published
1995-04-00
Pages
1545-52
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC295638
Subset
IM
Grants
NIDDK NIH HHS · DK-45066 · United States
NHLBI NIH HHS · HL-42488 · United States
External Links
PubMed source DOI: 10.1172/JCI117827 PMC Full Text View journal details
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