Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia.

CBFB MYH11 PKD1

Animals Base Sequence Biomarkers, Tumor/analysis Cell Transformation, Neoplastic/genetics Chromosome Fragility Chromosome Inversion Chromosome Mapping Chromosomes, Human, Pair 16/ultrastructure Cloning, Molecular Core Binding Factor Alpha 1 Subunit DNA-Binding Proteins/genetics Eosinophils/pathology Genes Humans Leukemia, Myelomonocytic, Acute/classification,genetics,pathology Mice Models, Genetic Molecular Sequence Data Myosins/genetics Neoplasm Proteins RNA, Messenger/genetics RNA, Neoplasm/genetics Recombinant Fusion Proteins/genetics Species Specificity Transcription Factor AP-2 Transcription Factors/genetics

Biomarkers, Tumor Core Binding Factor Alpha 1 Subunit DNA-Binding Proteins Neoplasm Proteins RNA, Messenger RNA, Neoplasm RUNX2 protein, human Recombinant Fusion Proteins Runx2 protein, mouse Transcription Factor AP-2 Transcription Factors Myosins