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PMID: 7733990 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains.

Biochemical and biophysical research communications ·Vol. 209 ·No. 3 ·1995-04-26 ·Pages 959-65

Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR

Abstract

We have isolated cDNAs from normal human breast tissue and breast tumour cells that encode a protein (pez) with features of a novel non-receptor tyrosine phosphatase possessing N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family. Northern blot analysis indicates that pez is expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta. Fluorescence in situ hybridization has mapped pez to chromosome 1 region q32.2-41. Sequence identity to a characterized polymorphic marker confirms this localization.

Related Genes
pez
MeSH Terms
Amino Acid Sequence Base Sequence Blotting, Northern Breast/metabolism Breast Neoplasms/metabolism Chromosome Mapping Chromosomes, Human, Pair 13 Cloning, Molecular Cytoskeletal Proteins DNA Primers DNA, Complementary/metabolism Female Gene Library Humans In Situ Hybridization, Fluorescence Molecular Sequence Data Phosphoproteins/biosynthesis,chemistry Polymerase Chain Reaction Protein Tyrosine Phosphatases/biosynthesis,chemistry,physiology Protein Tyrosine Phosphatases, Non-Receptor RNA, Messenger/isolation & purification,metabolism Sequence Homology, Amino Acid Tumor Cells, Cultured
Chemicals
Cytoskeletal Proteins DNA Primers DNA, Complementary Phosphoproteins RNA, Messenger ezrin PTPN14 protein, human Protein Tyrosine Phosphatases Protein Tyrosine Phosphatases, Non-Receptor
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Smith A L
Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
Mitchell P J
Shipley J
Gusterson B A
Rogers M V
Crompton M R
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
Published
1995-04-26
Pages
959-65
Language
English
Region
United States
NLM ID
0372516
Subset
IM
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