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PMID: 7734302 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region.

British journal of cancer ·Vol. 71 ·No. 5 ·1995-05-00 ·Pages 1070-3

Leggett B, Young J, Buttenshaw R, Thomas L, Young B, Chenevix-Trench G, Searle J, Ward M

Abstract

Allelic loss is a common mechanism of inactivation of tumour-suppressor genes in colorectal carcinomas. A number of known or putative tumour-suppressor genes including NF1, BRCA1, NME1, NME2 and prohibitin are present on the long arm of chromosome 17, and this region has not been extensively analysed in colorectal tumours. In this study 72 colorectal carcinomas were examined for allelic loss at eight loci on chromosome 17. Allelic loss was frequent both at the p53 locus, which is known to be important in colorectal carcinoma, and also telomeric to p53 on 17p. Allelic loss continued to be present in more than 50% of cases in the pericentromeric region and on proximal 17q to the marker LEW101 (D17S40) at 17q22-23. The most telomeric markers on 17q showed lower rates of allelic loss. Analysis of cases with partial deletions which did not include the p53 locus showed a common region of overlap of the deletions centred on D17S40. This suggests the target of allelic loss on 17q is a tumour-suppressor gene in this region.

Related Genes
APC BRCA1 K-ras MCC NF1 NME1 nm23-H1 p53
MeSH Terms
Alleles Chromosomes, Human, Pair 17 Colorectal Neoplasms/genetics,pathology Evaluation Studies as Topic Gene Deletion Genes, Overlapping Genes, p53 Humans Neoplasm Staging
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Leggett B
Glaxo Gastroenterology Research Laboratory, Royal Brisbane Hospital Clinical Research Centre, Bancroft Centre, Australia.
Young J
Buttenshaw R
Thomas L
Young B
Chenevix-Trench G
Searle J
Ward M
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1995.206
Published
1995-05-00
Pages
1070-3
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2033787
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1995.206 PMC Full Text View journal details
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