Glucose tolerance and insulin release, a mathematical approach I. Assay of the beta-cell response after oral glucose loading.

Diabetes ·Vol. 25 ·No. 4 ·1976-04-00 ·Pages 241-4

Sluiter WJ, Erkelens DW, Reitsma WD, Doorenbos H

Abstract

From the dose-response relations between glucose and insulin after oral glucose loading, a reproducible parameter for beta-cell response was deduced. The main advantage of this parameter -corrected insulin response, defined as CIR = I- 100/G(G-70)- lies in it independence from the initial or reached glucose level.

MeSH Terms

Dose-Response Relationship, Drug Glucose/pharmacology Glucose Tolerance Test Humans Insulin/metabolism Insulin Secretion Islets of Langerhans/drug effects Male Mathematics Models, Biological

Chemicals

Insulin Glucose

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Sluiter W J

Erkelens D W

Reitsma W D

Doorenbos H

Article Info

Journal

Diabetes

Abbr.

Diabetes

ISSN

0012-1797

DOI

10.2337/diab.25.4.241

Published

1976-04-00

Pages

241-4

Language

English

Region

United States

NLM ID

0372763

Subset

External Links

PubMed source DOI: 10.2337/diab.25.4.241 View journal details

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