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PMID: 7751012 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Migration of donor cells into the thymus is not essential for induction and maintenance of systemic tolerance after liver transplantation in the rat.

Immunology ·Vol. 84 ·No. 2 ·1995-02-00 ·Pages 333-6

Kobayashi E, Kamada N, Delriviere L, Lord R, Goto S, Walker NI, Enosawa S, Miyata M

Abstract

In this study, we show that cells encoded by donor-type major histocompatibility complex (MHC) class I antigens effectively migrate into the thymus of the host after liver transplantation. However, the thymus is not essential for the induction and maintenance of tolerance after orthotopic rat liver transplantation (OLT). Liver allografted rats in the DA(RT1a) into PVG (RT1c) combination survived without immunosuppressive agents. The thymus of the host showed a transitory atrophy and returned to normal weight 4 weeks after OLT. Donor antigens were detected in the host thymus after OLT. Adult PVG rats that had been thymectomized 1 week before implantation of DA liver grafts showed liver graft survival without immunosuppression. DA heart grafts were heterotopically transplanted into the PVG thymectomized, liver-grafted rats 1-4 weeks after OLT. No rejection of the cardiac allografts was observed. Systemic tolerance was induced and maintained in the absence of the thymus.

MeSH Terms

Animals Bone Marrow/immunology Cell Movement Graft Survival Histocompatibility Antigens Class I/immunology Immune Tolerance Immunoblotting Immunohistochemistry Liver Transplantation/immunology Organ Size Rats Rats, Inbred Strains Spleen/immunology Thymus Gland/anatomy & histology,immunology Transplantation Immunology Transplantation, Homologous

Chemicals

Histocompatibility Antigens Class I

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Kobayashi E

Department of Surgery, University of Queensland, Brisbane, Australia.

Kamada N

Delriviere L

Lord R

Goto S

Walker N I

Enosawa S

Miyata M

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1995-02-00

Pages

333-6

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1415086

Subset

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Migration of donor cells into the thymus is not essential for induction and maintenance of systemic tolerance after liver transplantation in the rat.

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