Abstract
Grafts of favorable axonal growth substrates were combined with transient nerve growth factor (NGF) infusions to promote morphological and functional recovery in the adult rat brain after lesions of the septohippocampal projection. Long-term septal cholinergic neuronal rescue and partial hippocampal reinnervation were achieved, resulting in partial functional recovery on a simple task assessing habituation but not on a more complex task assessing spatial reference memory. Control animals that received transient NGF infusions without axonal-growth-promoting grafts lacked behavioral recovery but also showed long-term septal neuronal rescue. These findings indicate that (i) partial recovery from central nervous system injury can be induced by both preventing host neuronal loss and promoting host axonal regrowth and (ii) long-term neuronal loss can be prevented with transient NGF infusions.
MeSH Terms
Acetylcholinesterase/analysis
Animals
Axons/drug effects,pathology,physiology
Brain Injuries/pathology,physiopathology,therapy
Brain Tissue Transplantation/pathology,physiology
Cerebral Ventricles/drug effects,physiology
Female
Fetal Tissue Transplantation
Habituation, Psychophysiologic/drug effects
Hippocampus/pathology,physiology
Infusions, Parenteral
Maze Learning/drug effects,physiology
Mice
Nerve Fibers/drug effects,pathology,physiology
Nerve Growth Factors/administration & dosage,pharmacology
Nerve Regeneration/drug effects
Neurons/drug effects,pathology,physiology
Rats
Rats, Inbred F344
Chemicals
Nerve Growth Factors
Acetylcholinesterase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tuszynski M H
Department of Neurosciences, University of California, San Diego, La Jolla 92093-0608, USA.
Gage F H
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