Insulin-stimulated polypeptide chain elongation in the soleus muscle of mice.

Bioscience, biotechnology, and biochemistry ·Vol. 59 ·No. 2 ·1995-02-00 ·Pages 348-9

Yoshizawa F, Tonouchi A, Miura Y, Yagasaki K, Funabiki R

Abstract

The effect of insulin on polypeptide chain elongation was examined in soleus muscles isolated from 18 hour-fasted mice. Treatment with insulin for 1 hour increased the elongation rate, which was estimated by the half-transit time. This suggests that insulin stimulated protein synthesis by modifying the elongation rate in addition to the initiation rate.

MeSH Terms

Animals Diabetes Mellitus, Experimental/metabolism Electrophoresis, Polyacrylamide Gel Insulin/administration & dosage,pharmacology Male Mice Muscle Proteins/biosynthesis Muscle, Skeletal/drug effects,metabolism Nerve Tissue Proteins/metabolism Peptide Biosynthesis Peptide Chain Elongation, Translational/drug effects Peptide Elongation Factor 1 Peptide Elongation Factor 2 Peptide Elongation Factors/metabolism Phosphorylation Ribonucleoproteins/metabolism

Chemicals

Insulin Muscle Proteins Nerve Tissue Proteins Peptide Elongation Factor 1 Peptide Elongation Factor 2 Peptide Elongation Factors Ribonucleoproteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Yoshizawa F

Department of Applied Biological Science, Tokyo Noko University, Japan.

Tonouchi A

Miura Y

Yagasaki K

Funabiki R

Article Info

Journal

Bioscience, biotechnology, and biochemistry

Abbr.

Biosci Biotechnol Biochem

ISSN

0916-8451

DOI

10.1271/bbb.59.348

Published

1995-02-00

Pages

348-9

Language

English

Region

England

NLM ID

9205717

External Links

PubMed source DOI: 10.1271/bbb.59.348 View journal details

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Insulin-stimulated polypeptide chain elongation in the soleus muscle of mice.

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