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PMID: 7773573 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.

Current opinion in lipidology ·Vol. 6 ·No. 2 ·1995-04-00 ·Pages 86-91

Mahley RW, Nathan BP, Bellosta S, Pitas RE

Abstract

Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.

MeSH Terms

Alzheimer Disease/etiology Apolipoprotein E3 Apolipoprotein E4 Apolipoproteins E/metabolism,pharmacology,physiology Cytoskeleton/physiology Humans Neurons/metabolism,ultrastructure

Chemicals

Apolipoprotein E3 Apolipoprotein E4 Apolipoproteins E

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Mahley R W

Gladstone Institute of Cardiovascular Disease, Department of Pathology, University of California, San Francisco, USA.

Nathan B P

Bellosta S

Pitas R E

Article Info

Journal

Current opinion in lipidology

Abbr.

Curr Opin Lipidol

ISSN

0957-9672

DOI

10.1097/00041433-199504000-00005

Published

1995-04-00

Pages

86-91

Language

English

Region

England

NLM ID

9010000

Subset

Grants

NHLBI NIH HHS · HL-41633 · United States

External Links

PubMed source DOI: 10.1097/00041433-199504000-00005 View journal details

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Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.

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