Expression of messenger RNA for somatostatin receptor subtype 4 in adult rat brain.

Neuroscience letters ·Vol. 188 ·No. 1 ·1995-03-16 ·Pages 17-20

Harrington KA, Schindler M, Humphrey PP, Emson PC

Abstract

The distribution and cellular localisation of somatostatin receptor subtype 4 (SSTR4) was investigated in the adult rat brain using the technique of in situ hybridisation with subtype specific oligonucleotide probes. Somatostatin receptor subtype 4 was found mainly in the hippocampus CA1 > CA2 > CA3 pyramidal cells and in the pyramidal cells in layers (IV-VI) of the cerebral cortex. Reverse transcription-PCR with SSTR4 specific primers confirmed the tissue distribution revealed by in situ hybridisation.

MeSH Terms

Animals Cerebellar Nuclei/metabolism Cerebral Cortex/metabolism Gene Expression Hippocampus/metabolism In Situ Hybridization Polymerase Chain Reaction Pyramidal Cells/metabolism RNA, Messenger/genetics,metabolism Rats Receptors, Somatostatin/genetics,metabolism

Chemicals

RNA, Messenger Receptors, Somatostatin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Harrington K A

Department of Neurobiology, Babraham Institute, Cambridge, UK.

Schindler M

Humphrey P P

Emson P C

Article Info

Journal

Neuroscience letters

Abbr.

Neurosci Lett

ISSN

0304-3940

DOI

10.1016/0304-3940(95)11382-7

Published

1995-03-16

Pages

17-20

Language

English

Region

Ireland

NLM ID

7600130

Subset

External Links

PubMed source DOI: 10.1016/0304-3940(95)11382-7 View journal details

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Expression of messenger RNA for somatostatin receptor subtype 4 in adult rat brain.

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