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PMID: 7784062 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.

Oncogene ·Vol. 10 ·No. 11 ·1995-06-01 ·Pages 2179-83

Gray DA, Inazawa J, Gupta K, Wong A, Ueda R, Takahashi T

Abstract

The murine Unp proto-oncogene encodes a nuclear ubiquitin protease whose overexpression leads to oncogenic transformation of NIH3T3 cells. We have cloned cDNAs originating from the human homolog of this gene, designated herein as Unph (Unp, human), and have used these cDNAs to map the gene to 3p21.3, a region frequently rearranged in human tumor cells. Unph mRNA levels are consistently elevated in small cell tumors and adenocarcinomas of the lung, suggesting a possible causative role for the gene in the neoplastic process.

Related Genes
Unph
MeSH Terms
3T3 Cells Adenocarcinoma/genetics Amino Acid Sequence Animals Base Sequence Carcinoma, Small Cell/genetics Chromosomes, Human, Pair 3 DNA, Complementary Gene Expression Regulation, Neoplastic Humans Lung Neoplasms/genetics Mice Molecular Sequence Data Oncogene Proteins/genetics Proto-Oncogene Mas Proto-Oncogene Proteins Sequence Homology, Amino Acid Ubiquitin Thiolesterase Ubiquitin-Specific Proteases
Chemicals
DNA, Complementary MAS1 protein, human Oncogene Proteins Proto-Oncogene Mas Proto-Oncogene Proteins USP4 protein, human Usp4 protein, mouse Ubiquitin Thiolesterase Ubiquitin-Specific Proteases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Gray D A
Department of Medicine, University of Ottawa, Canada.
Inazawa J
Gupta K
Wong A
Ueda R
Takahashi T
Article Info
Journal
Oncogene
Abbr.
Oncogene
ISSN
0950-9232
Published
1995-06-01
Pages
2179-83
Language
English
Region
England
NLM ID
8711562
Subset
IM
Databases
GENBANK
U20657
External Links
PubMed source View journal details
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