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PMID: 7790621 Published · ppublish English Journal Article Review

Neutrophil-mediated tissue injury and its modulation.

Intensive care medicine ·Vol. 21 ·No. 3 ·1995-03-00 ·Pages 277-85

Fujishima S, Aikawa N

Abstract

Neutrophils play a key role in the development of the systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Since the lungs are the main target in these syndromes, with adult respiratory distress syndrome (ARDS) as the outcome, extensive research has been undertaken to prevent or mitigate ARDS. As evidence of the involvement of neutrophils in ARDS has accumulated, modulation of their function has become a major goal in terms of a therapeutic approach. In this short review, we sought to update our knowledge about neutrophils. Firstly, we summarized the various stimuli which activate neutrophils. Secondly, we described the different mediators, including cytokines, which are released by neutrophils. Lastly, we discussed the possible modulation of their function. Although we cannot assess the clinical usefulness of biochemical substances merely on the basis of their in vitro effects, understanding these mechanisms is fundamental to the success of the new therapeutic approach which is currently under way.

MeSH Terms
Cytokines/physiology Humans Multiple Organ Failure/immunology,therapy Neutrophils/drug effects,physiology Respiratory Distress Syndrome/immunology Systemic Inflammatory Response Syndrome/immunology,therapy
Chemicals
Cytokines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fujishima S
Department of Emergency Medicine, School of Medicine, Keio University, Tokyo, Japan.
Aikawa N
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Article Info
Journal
Intensive care medicine
Abbr.
Intensive Care Med
ISSN
0342-4642
DOI
10.1007/BF01701489
Published
1995-03-00
Pages
277-85
Language
English
Region
United States
NLM ID
7704851
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01701489 View journal details
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