Structural features of the uniporter/symporter/antiporter superfamily.
The uniporter/symporter/antiporter superfamily is an evolutionarily related group of solute transporters. For the entire superfamily, we have used a new predictive program to identify the transmembrane domains. These transmembrane domains were then analyzed with regard to their overall hydrophobicity and amphipathicity. In addition, the lengths of the hydrophilic loops connecting the transmembrane domains were calculated. These data, together with structural information in the literature, were collectively used to produce a general model for the three-dimensional arrangement of the transmembrane domains.
15 references, click to expand
-
A simple method for displaying the hydropathic character of a protein.J Mol Biol. 1982 May 5;157(1):105-32 PMID: 7108955
-
A model recognition approach to the prediction of all-helical membrane protein structure and topology.Biochemistry. 1994 Mar 15;33(10):3038-49 PMID: 8130217
-
A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose.Mol Gen Genet. 1985;198(3):473-5 PMID: 3892229
-
Mammalian and bacterial sugar transport proteins are homologous.Nature. 1987 Feb 12-18;325(6105):641-3 PMID: 3543693
-
Isolation and characterization of lactose permease mutants with an enhanced recognition of maltose and diminished recognition of cellobiose.J Biol Chem. 1989 Sep 5;264(25):14698-703 PMID: 2670925
-
Isolation and characterization of thiodigalactoside-resistant mutants of the lactose permease which possess an enhanced recognition for maltose.J Biol Chem. 1989 Sep 25;264(27):15988-92 PMID: 2674122
-
Nobel lecture. The photosynthetic reaction centre from the purple bacterium Rhodopseudomonas viridis.EMBO J. 1989 Aug;8(8):2149-70 PMID: 2676514
-
Proton-linked sugar transport systems in bacteria.J Bioenerg Biomembr. 1990 Aug;22(4):525-69 PMID: 2172229
-
The interaction between aspartic acid 237 and lysine 358 in the lactose carrier of Escherichia coli.Biochim Biophys Acta. 1991 Feb 25;1062(2):177-86 PMID: 1848449
-
Membrane transport proteins: implications of sequence comparisons.Curr Opin Cell Biol. 1992 Aug;4(4):684-95 PMID: 1419050
-
A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.Trends Biochem Sci. 1993 Jan;18(1):13-20 PMID: 8438231
-
Lysine 319 interacts with both glutamic acid 269 and aspartic acid 240 in the lactose carrier of Escherichia coli.J Biol Chem. 1993 Sep 25;268(27):20007-15 PMID: 8104184
-
Identification of a residue in the translocation pathway of a membrane carrier.Cell. 1993 Oct 8;75(1):37-44 PMID: 8402899
-
Use of site-directed fluorescence labeling to study proximity relationships in the lactose permease of Escherichia coli.Biochemistry. 1993 Nov 23;32(46):12273-8 PMID: 8241112
-
Does the lactose carrier of Escherichia coli function as a monomer?FEBS Lett. 1983 Oct 3;162(1):11-5 PMID: 6352333
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
