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PMID: 7815556 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.

Journal of virology ·Vol. 69 ·No. 2 ·1995-02-00 ·Pages 882-8

Rogel ME, Wu LI, Emerman M

Abstract

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that can cause extensive cytopathicity in T cells. However, long-term productive infection of T-cell lines has been described. Here we show that although Vpr has no effect on the initial cytopathic effect of HIV-1, viruses that contain an intact vpr gene are unable to establish a chronic infection of T cells. However, virus with a mutated vpr gene can readily establish such long-term cultures. The effect of Vpr is independent of the env gene and the nef gene. Furthermore, expression of Vpr alone affects the progression of cells in the cell cycle. These results suggest that HIV-1 has evolved a viral gene to prevent chronic infection of T cells.

Related Genes
vpr
MeSH Terms
Cell Cycle Cell Death Cell Division Cell Line Genes, vpr/physiology HIV-1/genetics Humans Mutation Open Reading Frames Proto-Oncogene Proteins/physiology Proto-Oncogene Proteins c-bcl-2
Chemicals
Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rogel M E
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Wu L I
Emerman M
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.2.882-888.1995
Published
1995-02-00
Pages
882-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC188655
Subset
IM
Grants
NIAID NIH HHS · R01 AI30927 · United States
External Links
PubMed source DOI: 10.1128/JVI.69.2.882-888.1995 PMC Full Text View journal details
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