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PMID: 7841059 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Plasminogen activators and inhibitor type 1 in neoplastic colonic tissue from patients with familial adenomatous polyposis.

British journal of cancer ·Vol. 71 ·No. 2 ·1995-02-00 ·Pages 393-6

Sier CF, Vloedgraven HJ, Griffioen G, Ganesh S, Nagengast FM, Lamers CB, Verspaget HW

Abstract

The plasminogen activation cascade is involved in carcinogenesis, invasion and metastasis. In this study plasminogen activators and their type 1 inhibitor were evaluated in colonic tissue from 19 patients with familial adenomatous polyposis coli, an inherited disorder characterised by the presence of thousands of adenomatous polyps in the colorectum which predispose to colorectal cancer. The conversion of normal-appearing colonic mucosa to neoplastic tissue in these patients was associated with an increase in urokinase-type plasminogen activator and plasminogen activator inhibitor type 1, accompanied by a decreased level of tissue-type plasminogen activator. These observations are essentially similar to those found in solitary adenomas and carcinomas of the colon, and illustrate the uniform involvement of the plasminogen activation system in colorectal carcinogenesis.

MeSH Terms
Adenocarcinoma/chemistry,genetics Adenomatous Polyposis Coli/metabolism Adenomatous Polyps/chemistry,genetics Biomarkers, Tumor/analysis Carcinoma in Situ/chemistry,genetics Colonic Neoplasms/chemistry,genetics Colonic Polyps/chemistry,genetics Humans Neoplasm Proteins/analysis Plasminogen Activator Inhibitor 1/analysis Plasminogen Activators/analysis Tissue Plasminogen Activator/analysis Urokinase-Type Plasminogen Activator/analysis
Chemicals
Biomarkers, Tumor Neoplasm Proteins Plasminogen Activator Inhibitor 1 Plasminogen Activators Tissue Plasminogen Activator Urokinase-Type Plasminogen Activator
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Sier C F
Department of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
Vloedgraven H J
Griffioen G
Ganesh S
Nagengast F M
Lamers C B
Verspaget H W
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1995.80
Published
1995-02-00
Pages
393-6
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2033606
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1995.80 PMC Full Text View journal details
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